Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Heavy metal toxicity and bioaccumulation caused severe damage to soil, water environment as a result of industrialization/urbanization activities in developing developed countries. This has affected different trophic levels including plants, animals humans become global concern. The use various phytonutrients such Quercetin (QE) increased recent years avoid by heavy metals. Among metals, cadmium (Cd) is major issue the Cd toxic that can kidneys cause dysregulation many lipid metabolic pathways. However, number studies on renal dysfunction dyslipidemia limited. We found causes dyslipidemia, QE ameliorates these Cd-induced damages. Our results showed urea, uric acid, creatnine, alkene phosphatase (ALP), total bilirubin (TBIL) compared control group, while improved other parameters except TBIL. In addition, our findings glyceride (TG), cholesterol (TC), low-density lipoprotein (LDL) lactate dehydrogenase (LDH) decreased high-density (HDL) levels. It was noted tended improve this picture. data presented here demonstrated clear protective role against function through its hypolipidemic antioxidative action.